1Kwang Hwi Lee,1Jiyeong Lee

1Sheikh Khalifa Specialty Hospital


Fine needle aspiration (FNA) has been applied for thyroid nodules, as a first-line diagnostic method for several decades. Core needle biopsy (CNB) has been suggested as a supplementary diagnostic tool for thyroid nodules recently. The purpose of this study is to compare diagnostic efficacy between FNA and CNB, and to evaluate diagnostic value of CNB as a first-line diagnostic method.

Material(s) and Method(s):

From 2015 to 2021, 60 patients underwent FNA (M:F= 17:43, mean age: 43 years) and 253 patients underwent CNB (M:F= 54:199, mean age: 48.2 years) were enrolled. Pathologic evaluation was classified using same categories in both methods, based on Bethesda classification: I: non-diagnostic, II: benign, III: indeterminate, IV: follicular neoplasm, V: suspected malignancy and VI: malignancy.


The pathologic results of FNA vs CNB were 21.6% vs 3.6% in category I, 44.3% vs 42.2% in category II, 14.8% vs 9.2% in category III, 2.3% vs 27.8% in category IV, 10.2% vs 6% in category V and 6.8% vs 11.2% in category VI (p< 0.05). Inconclusive rate of FNA vs CNB was 36.4% vs 12.8% (p< 0.001). Malignant rate of FNA vs CNB was 4.1% vs 0.5% in category I, 5.4% vs 1.2% in category II, 15.2% vs 7.8% in category III, 0% vs 17% in category IV, 100% vs 95% in category V and 100% vs 100% in category VI (p> 0.05).


CNB was superior to FNA reducing inconclusive rate for thyroid nodules. CNB can be applied as an alternative first-line diagnostic method for thyroid nodules.